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1996-03-09
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Document 0270
DOCN M9650270
TI Detection of Pneumocystis carinii, Mycobacterium tuberculosis, and
cytomegalovirus in human immunodeficiency virus (HIV)-infected patients
with hemophilia by polymerase chain reaction of induced sputum samples.
DT 9605
AU Shimomoto H; Hasegawa Y; Takagi N; Ichiyama S; Takamatsu J; Saito H;
Shimokata K; First Department of Internal Medicine, Nagoya University
School; of Medicine.
SO Intern Med. 1995 Oct;34(10):976-81. Unique Identifier : AIDSLINE
MED/96157629
AB The purpose of this study was to diagnose the initial stage of acute
pulmonary infections due to Pneumocystis carinii (P. carinii),
Mycobacterium tuberculosis (M. tuberculosis), and cytomegalovirus (CMV)
by polymerase chain reaction (PCR) combined with the induced sputum
method in hemophilia patients infected with human immunodeficiency virus
(HIV). Induced sputum and PCR were obtained at each outpatient visit or
when any respiratory symptoms were present during a one-year period. All
patients with a CD4+ count of less than 200 x 10(6)/l were given
prophylactics against P. carinii pneumonia (PCP). PCR was conducted 111
times in 29 patients. M. tuberculosis DNA was detected in 1 patient and
CMV DNA in 4 patients. P. carinii DNA was not detected. PCR on induced
sputum samples is sensitive for the rapid detection of the initial stage
of respiratory events. PCP prophylaxis changes the clinical
manifestations of HIV infection.
DE Adolescence Adult AIDS-Related Opportunistic
Infections/*DIAGNOSIS/MICROBIOLOGY Base Sequence
Cytomegalovirus/*ISOLATION & PURIF Cytomegalovirus
Infections/*DIAGNOSIS/VIROLOGY CD4 Lymphocyte Count DNA,
Bacterial/ANALYSIS DNA, Fungal/ANALYSIS DNA, Viral/ANALYSIS
Hemophilia/*COMPLICATIONS Human Male Molecular Sequence Data
Mycobacterium tuberculosis/*ISOLATION & PURIF Oxygen/BLOOD
Pneumocystis carinii/*ISOLATION & PURIF Pneumonia, Pneumocystis
carinii/*DIAGNOSIS/MICROBIOLOGY Polymerase Chain Reaction
Sputum/*MICROBIOLOGY Tuberculosis/DIAGNOSIS/MICROBIOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).